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Phys.org)—A team of chemists at Ludwig Maximilian University of Munich has shown how the purines adenine and guanine can be synthesized easily and in reasonable yields, offering more evidence that RNA could have served as the origin of life on Earth. In their paper published in the journal Science, the team describes the process they took in looking for evidence that RNA could have been the first self-replicating molecule that event
More information: S. Becker et al. A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway, Science (2016). DOI: 10.1126/science.aad2808
The origin of life is believed to have started with prebiotic molecules reacting along unidentified pathways to produce key molecules such as nucleosides. To date, a single prebiotic pathway to purine nucleosides had been proposed. It is considered to be inefficient due to missing regioselectivity and low yields. We report that the condensation of formamidopyrimidines (FaPys) with sugars provides the natural N-9 nucleosides with extreme regioselectivity and in good yields (60%). The FaPys are available from formic acid and aminopyrimidines, which are in turn available from prebiotic molecules that were also detected during the Rosetta comet mission. This nucleoside formation pathway can be fused to sugar-forming reactions to produce pentosides, providing a plausible scenario of how purine nucleosides may have formed under prebiotic conditions.
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(Phys.org) —One of the biggest questions in science is how life arose from the chemical soup that existed on early Earth. One theory is that RNA, a close relative of DNA, was the first genetic molecule to arise around 4 …
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